ea0016p288 | Endocrine tumours | ECE2008
Catalano Maria Graziella
, Pugliese Mariateresa
, Bosco Ornella
, Fortunati Nicoletta
, Boccuzzi Giuseppe
Poorly differentiated and anaplastic thyroid carcinomas are aggressive human cancers that are resistant to conventional therapy. DAC inhibitors (DACi) are a promising class of drugs, acting as anti-proliferative agents by inducing apoptosis and cell cycle arrest.Panobinostat (LBH589) is a potent DACi belonging to a structurally novel cinnamic hydroxamic acid class of compounds, able to inhibit the activity of different isoforms of HDACs (HDAC 1, 36...